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Nick
E. Goeders,
Ph.D.
Professor and Head
Department of Pharmacology, Toxicology and Neuroscience
Director, Stress and the Neurobiology of Drug and Alcohol Dependence Training Program
Ph.D.,
1984, LSU Medical Center, Shreveport
Major Research
Interests:
We have been investigating the role for stress and the subsequent activation of the hypothalamo-pituitary-adrenal (HPA) axis in the etiology of drug addiction for several years now and have shown that HPA axis activation is important for the acquisition of drug seeking as well as the reinstatement of extinguished drug seeking (relapse). We employ a variety of techniques including intravenous drug self-administration, in vivo microdialysis, neurotoxin lesions, and receptor analysis combined with pharmacological, behavioral and environmental interventions. We also investigate the effects of manipulations of HPA axis and gonadal hormones on the neurobiology of drug addiction. Major classes of drugs under investigation include cocaine and methamphetamine. Our ultimate goal is the identification of novel pharmacotherapies based on manipulations of HPA axis activity by translating the results of our preclinical studies into clincal research.
Selected recent publications:
Goeders, N.E. and G.F. Guerin. Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats. Neuropsychopharmacology 23; 577-586, 2000.
Goeders, N.E. Stress and cocaine addiction. (Perspectives in Pharmacology) Journal of Pharmacology and Experimental Therapeutics 301(3):785-9, 2002.
Goeders, N.E. and D.M. Clampitt. Potential role for the HPA axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology 161(3): 222-232, 2002.
Goeders, N.E.
The HPA axis and cocaine reinforcement. Psychoneuroendocrinology 27:
13-33, 2002.
Contact Info:
Dr. Nick E. Goeders
Professor and Director
Stress and the Neurobiology of Drug and Alcohol Dependence Training
Program
Louisiana State University Health Sciences Center
1501 Kings Highway
Shreveport, LA 71130-3932
318-675-7863
ngoede@lsuhsc.edu